A global view of regulatory networks in lung cancer: An approach to understand homogeneity and heterogeneity

作者：Lu Jiapei; Wang William; Xu Menglin; Li Yuping; Chen Chengshui; Wang Xiangdong

来源：Seminars in Cancer Biology, 2017, 42: 31-38.

DOI：10.1016/j.semcancer.2016.11.004

• Lung cancer
• Regulatory network
• Transcriptional factor
• Subtype
• Bioinformatics

A number of new biotechnologies are used to identify potential biomarkers for the early detection of lung cancer, enabling a personalized therapy to be developed in response. The combinatorial cross-regulation of hundreds of biological function-specific transcription factors (TFs) is defined as the understanding of regulatory networks of molecules within the cell. Here we integrated global databases with 537 patients with lung adenocarcinoma (ADC), 140 with lung squamous carcinoma (SCC), 9 with lung large-cell carcinoma (LCC), 56 with small-cell lung cancer (SCLC), and 590 without cancer with the understanding of TF functions. The present review aims at the homogeneity or heterogeneity of gene expression profiles among subtypes of lung cancer. About 5,136, 52, or 16 up-regulated or 19, 24,122, or 97down-regulated type-special TF genes were identified in ADC, SCC, LCC or SCLC, respectively. DNA-binding and transcription regulator activity associated genes play a dominant role in the differentiation of subtypes in lung cancer. Subtype-specific TF gene regulatory networks with elements should be an alternative for diagnostic and therapeutic targets for early identification of lung cancer and can provide insightful clues to etiology and pathogenesis.

• 出版日期2017-2
• 单位温州医科大学