Adverse effects of a 10-day course of ibuprofen in Holstein calves

作者：Walsh P; Chaigneau F R Carvallo; Anderson M; Behrens N; Mceligot H; Gunnarson B; Gershwin L J

来源：Journal of Veterinary Pharmacology and Therapeutics, 2016, 39(5): 518-521.

DOI：10.1111/jvp.12295

Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for various conditions in cattle. Ibuprofen is an inexpensive short-acting NSAID and is readily available in liquid formulation for administration to bottle-fed calves. We compared the adverse effects of a 10-day course of ibuprofen and placebo in 16 five-to six-week-old Holstein bull calves that were being treated for experimentally induced bovine respiratory syncytial virus infection. Ibuprofen was administered as a liquid in milk replacer at 30 mg/kg divided three times daily. We found an increased prevalence of abomasal ulceration 5 of 8 in the ibuprofen compared to placebo group 2 of 6 (P = NS). There was one (1 of 8) case of mild interstitial nephritis in the ibuprofen and none (0 of 8) in the placebo group (P = NS). Renal function as measured by serum BUN and creatinine levels was not different between groups; no animal demonstrated an increase in creatinine.

• 出版日期2016-10