Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism

作者：Kooiman Judith^*; den Exter Paul L; Kilicsoy Inci; Cannegieter Suzanne C; Eikenboom Jeroen; Huisman Menno V; Klok Frederikus A; Versteeg Henri H

来源：Journal of Thrombosis and Thrombolysis, 2015, 40(3): 323-330.

DOI：10.1007/s11239-015-1180-z

• Pulmonary embolism
• Recurrent venous thromboembolism
• Micro particle-tissue factor
• Factor VIII activity
• Epidemiology

Studies on the association between microparticle expressing tissue factor (MP-TF) activity, FVIII activity (FVIII:C) and recurrent VTE yielded inconclusive results. We studied these associations in patients diagnosed with acute pulmonary embolism. Plasma levels of MP-TF and FVIII activity were measured in 277 patients with a first and 72 patients with a recurrent VTE. All patients were categorized based on the quintiles of MP-TF and FVIII activity in those with a single VTE. For both markers, odds ratios (ORs) for recurrent VTE were computed using patients in the lowest quintile as a reference group. No association was observed between MP-TF activity and recurrent VTE, with an OR of 1.4 (95 % CI 0.7-2.9) in the highest quintile of MP-TF activity. Compared with the reference group, patients in the highest quintile of FVIII:C were at increased risk of recurrent VTE, OR 4.2 (95 % CI 1.4-12.2). MP-TF activity was not associated with recurrent VTE whereas high FVIII:C levels were associated with a 4-fold increased risk of VTE recurrence. Future prospective studies are necessary to explore the potential of FVIII:C as a tool for risk stratification, either by itself or in combination with other pro-thrombotic markers.

• 出版日期2015-10