A New Friedelane Triterpenoid Possessing Cytotoxicity from the Leaves and Stems OF Drypetes hainanensis

作者：Chen, Deli^*; Cheng, Xu; Sun, Yuwan; Liu, Pinghuai

来源：Chemistry of Natural Compounds, 2014, 50(1): 93-96.

DOI：10.1007/s10600-014-0874-3

• Drypetes hainanensis
• Euphorbiaceae
• friedelane
• cytotoxic activity

Phytochemical studies on the EtOH extract of Drypetes hainanensis leaves and stems afforded a new friedelane-type triterpene named 4 beta-hydroxy-23-nor-friedel-3-one (1), along with seven known compounds: friedelin (2), diethylhexyl phthalate (3), alpha-amyrin (4), beta-amyrin (5), lupeol (6), friedelane-3,7-dione (7) and beta-sitosterol (8). Their structures were established on the basis of spectroscopic analysis and chemical evidence. The cytotoxicity of the selected compounds 1, 2, and 7 were evaluated in vitro against three human cancer cell lines (HL-60, BEL-7402, and A549). Compounds 1 and 7 showed moderate cytotoxic activity.

• 出版日期2014-3
• 单位海南大学