Preparation of biodegradable magnetic microspheres with poly(lactic acid)-coated magnetite

作者：Zhao Hong; Saatchi Katayoun; Haefeli Urs O

来源：Journal of Magnetism and Magnetic Materials, 2009, 321(10): 1356-1363.

DOI：10.1016/j.jmmm.2009.02.038

• Magnetite
• Coating
• Stabilization
• PLA
• PLGA
• Poly(lactic acid)
• Poly (lactide-co-glycolide)
• Magnetic microspheres
• Biodegradability

Poly(lactic acid) (PLA)-coated magnetic nanoparticles were made using uncapped PLA with free carboxylate groups. The physical properties of these particles were compared to those of oleate-coated or oleate/sulphonate bilayer (W40) coated magnetic particles. Magnetic microspheres (MMS) with the matrix material poly(lactide-co-glycolide) (PLGA) or PLA were then formed by the emulsion solvent extraction method with encapsulation efficiencies of 40%, 83% and 96% for oleate, PLA and oleate/sulfonate-coated magnetic particles, respectively. MMS made from PLA-coated magnetite were hemocompatible and produced no hemolysis, whereas the other MMS were hemolytic above 0.3mg/mL of blood.

• 出版日期2009-5