Hybrid intelligent control of substrate feeding for industrial fed-batch chlortetracycline fermentation process

作者：Jin, Huaiping^*; Chen, Xiangguang; Yang, Jianwen; Wu, Lei; Wang, Li

来源：ISA Transactions, 2014, 53(6): 1822-1837.

DOI：10.1016/j.isatra.2014.08.015

• Process control
• Substrate feeding
• Hybrid intelligent control
• Soft sensor
• Fed-batch fermentation process

The lack of accurate process models and reliable online sensors for substrate measurements poses significant challenges for controlling substrate feeding accurately, automatically and optimally in fed-batch fermentation industries. It is still a common practice to regulate the feeding rate based upon manual operations. To address this issue, a hybrid intelligent control method is proposed to enable automatic substrate feeding. The resulting control system consists of three modules: a presetting module for providing initial set-points; a predictive module for estimating substrate concentration online based on a new time interval-varying soft sensing algorithm; and a feedback compensator using expert rules. The effectiveness of the proposed approach is demonstrated through its successful applications to the industrial fed-batch chlortetracycline fermentation process.

• 出版日期2014-11
• 单位北京理工大学