Acute Motor-dominant Polyneuropathy as Guillain-Barre Syndrome and Multiple Mononeuropathies in a Patient with Sjogren's Syndrome

作者：Tanaka Kenichiro^*; Nakayasu Hiroyuki; Suto Yutaka; Takahashi Shotaro; Konishi Yoshihiro; Nishimura Hirotake; Ueno Rino; Kusunoki Susumu; Nakashima Kenji

来源：Internal Medicine, 2016, 55(18): 2717-2722.

DOI：10.2169/internalmedicine.55.6881

• Sjogren's syndrome
• Guillain-Barre syndrome
• antiganglioside antibody

A patient with xerostomia and xerophthalmia due to Sjogren's syndrome presented with acute motor-dominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barre syndrome and multiple mononeuropathy via Sjogren's syndrome. We speculate that Guillain-Barre syndrome occurred in the patient and Guillain-Barre syndrome itself activated multiple mononeuropathy via Sjogren's syndrome.

• 出版日期2016