科研之友
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摘要
Bioassay-guided fractionation of the whole plants of Saussurea deltoidea led to the isolation and structure elucidation of one new sesquiterpene, deltoidealactone (1), together with 23 known compounds 2-24. Their structures were established on the basis of extensive 1D- and 2D-NMR analyses in combination with HR-MS experiments. Deltoidealactone (1) inhibits tumor necrosis factor (TNF-alpha) production in U937 cells in vitro with an IC(50) value of 1.47 mu g/ml.
- 出版日期2011-8
