A Novel Tripeptide Derived from Chlorella vulgaris Regulates Skin Homeostasis Through Its Antioxidant Function

作者：Han Jae Gap; Kulkarni Atul; Jeon Jin Young; Kim Bo Ra; Song Mi Young; Jeong Hee Yong; Yang Dong Joo; You Seung Hun; Kim Ki Woo; Moh Sang Hyun^*; Hwang Jae Kwan

来源：Science of Advanced Materials, 2015, 7(12): 2545-2550.

DOI：10.1166/sam.2015.2440

• Chlorella vulgaris
• CAS Tripeptide
• Anti-Oxidation
• Anti-Aging

Marine green alga Chlorella vulgaris produces secondary metabolitesincluding functional nutrients and associated bioactive peptides to protect harmful and environmental stresses. These evidences suggest that Chlorella vulgaris extracts have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In this study, we newly identified cysteine-alanine-serine (CAS) tripeptide from Chlorella vulgaris using LC-MS/MS and NMR. We investigated whether the identified CAS has beneficial effect of the protection from ROS species on skin cells. CAS was treated on the human skin cell line and this resulted in increment of anti-oxidant genes. In addition, we identified the significant induction of procollagen C endopeptidase enhancer (PCOLCE) which is related to skin firming by CAS. Combined all together, these results suggest that microalgae-derived CAS tripeptidemight be a valuable biomaterial in modulating skin homeostasis through its antioxidant function.

• 出版日期2015-12