A formal synthesis of (-)-cephalotaxine

作者：Esmieu William R; Worden Stephen M; Catterick David; Wilson Claire; Hayes Christopher J^*

来源：Organic Letters, 2008, 10(14): 3045-3048.

DOI：10.1021/ol8010166

An enantioselective formal synthesis of the alkaloid (-)-cephalotaxine has been completed, using an alkylidene carbene 1,5-CH insertion reaction as a key step to construct the spiro[4.4]azanonane core D/E-ring system. A Heck-type cyclization was used to close the tetrahydroazepine C-ring and a selective epoxidation-rearrangement sequence was used to elaborate the E-ring.

• 出版日期2008-7-17