摘要
Dinuclear metal complexes have emerged as a promising class of unusually biologically active compounds. Acylpyrazolonato-bridged arene ruthenium complexes of the general formula [(arene)(2)Ru-2(L') Cl-2] were synthesized in methanol by reacting the arene ruthenium dimer [(arene) RuCl2](2) with the corresponding acylpyrazolone ligands. The complexes were isolated and fully characterized by spectroscopic methods; the single-crystal X-ray structure analysis of [(cymene)(2)Ru-2(L-1) Cl-2] is also presented. These ruthenium complexes were found to be cytotoxic towards epithelial cancerous cell lines to a comparable extent to cisplatin but with higher capacity to discriminate between normal and cancer cells.
- 出版日期2015-8-15