Dinuclear (eta(6)-arene) ruthenium(II) acylpyrazolone complexes: Synthesis, characterization and cytotoxicity

作者:Pettinari Riccardo*; Marchetti Fabio; Pettinari Claudio; Petrini Agnese; Skelton Brian W; White Allan H; Bonfili Laura; Cuccioloni Massimiliano; Eleuteri Anna Maria
来源:Journal of Organometallic Chemistry, 2015, 791: 1-5.
DOI:10.1016/j.jorganchem.2015.04.049

摘要

Dinuclear metal complexes have emerged as a promising class of unusually biologically active compounds. Acylpyrazolonato-bridged arene ruthenium complexes of the general formula [(arene)(2)Ru-2(L') Cl-2] were synthesized in methanol by reacting the arene ruthenium dimer [(arene) RuCl2](2) with the corresponding acylpyrazolone ligands. The complexes were isolated and fully characterized by spectroscopic methods; the single-crystal X-ray structure analysis of [(cymene)(2)Ru-2(L-1) Cl-2] is also presented. These ruthenium complexes were found to be cytotoxic towards epithelial cancerous cell lines to a comparable extent to cisplatin but with higher capacity to discriminate between normal and cancer cells.

  • 出版日期2015-8-15