Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes

作者：De Amicis Karine M; de Barros Samar Freschi; Alencar Raquel E; Postol Edilberto; Martins Carlo de Oliveira; Arcuri Helen Andrade; Goulart Cibelly; Kalil Jorge; Guilherme Luiza^*

来源：Vaccine, 2014, 32(32): 4104-4110.

DOI：10.1016/j.vaccine.2013.08.043

• Streptococcus pyogenes
• Vaccine
• Rheumatic fever
• Immunization coverage
• Immune response

Streptococcus pyogenes is responsible for infections as pharyngitis, sepsis, necrotizing fasciitis and streptococcal toxic shock syndrome. The M protein is the major bacterial antigen and consists of both polymorphic N-terminal portion and a conserved region. In the present study, we analyzed the in vitro ability of StreptInCor a C-terminal candidate vaccine against S. pyogenes to induce antibodies to neutralize/opsonize the most common S. pyogenes strains in Sao Paulo by examining the recognition by sera from StreptInCor immunized mice. We also evaluated the presence of cross-reactive antibodies against human heart valve tissue. Anti-StreptInCor antibodies were able to neutralize/opsonize at least 5 strains, showing that immunization with StreptInCor is effective against several S. pyogenes strains and can prevent infection and subsequent sequelae without causing autoimmune reactions.

• 出版日期2014-7-7