A new proline-containing flavonol glycoside from Caragana leucophloea Pojark

作者：Luo, Chao; Wang, Ali; Wang, Xiaohan; Li, Jing; Liu, Hongwei; Wang, Mingan; Wang, Lan; Lai, Daowan^*; Zhou, Ligang

来源：Natural Product Research, 2015, 29(19): 1811-1819.

DOI：10.1080/14786419.2015.1007974

• Caragana leucophloea Pojark
• Leguminosae
• flavonoids
• kaempferol-3-O-methyl-7-O--d-glucopyranosyl-8-(1-methyleneproline)-4-O-- d-glucopyranoside
• biological activities

One new proline-containing flavonol glycoside, namely kaempferol-3-O-methyl-7-O--d-glucopyranosyl-8-(1-methyleneproline)-4-O--d-glucopyranoside (1), together with 15 known flavonoids, 3-O-methylkaempferol (2), 3-O-methylquercetin (3), quercetin (4), kaempferol (5), apigenin (6), rhamnazin (7), astragalin (8), alquds (9), quercitrin (10), rutin (11), isoquercitrin (12), apigetrin (13), myricitrin (14), hesperidin (15) and calycosin-7-O--d-glucopyranoside (16) were isolated from the aerial parts of Caragana leucophloea Pojark. (Leguminosae). Their structures were determined on the basis of spectroscopic analyses and by comparison with literature data. Compounds 2-4 revealed a strong antimicrobial activity with minimum inhibitory concentration values of 12.5-150g/mL and median inhibitory concentration (IC50) values of 7.42-76.61g/mL. Compounds 3, 4, 6-8, 10-12 and 14 showed strong antioxidant activity. Compounds 2-7 exhibited moderate antinematodal activity on Caenorhabditis elegans with IC50 values of 40.51-68.05g/mL.

• 出版日期2015-10-2
• 单位中国农业大学; 塔里木大学