mTOR Signaling in Aging and Aging-associated Diseases

作者:He Jie-Yu; Liu Feng*
来源:Progress in Biochemistry and Biophysics, 2014, 41(3): 257-265.
DOI:10.3724/SP.J.1206.2014.00007

摘要

Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established, but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin (mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging, the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.