Analysis of Pathologic Extent of Disease for Clinically Localized Prostate Cancer After Radical Prostatectomy and Subsequent Use of Adjuvant Radiation in a National Cohort

作者：Schreiber David^*; Rineer Justin; Yu James B; Olsheski Michelle; Nwokedi Emmanuel; Schwartz David; Choi Kwang; Rotman Marvin

来源：Cancer, 2010, 116(24): 5757-5766.

DOI：10.1002/cncr.25561

• prostate cancer
• radical prostatectomy
• radiation
• Surveillance Epidemiology and End Results program
• adjuvant radiation

BACKGROUND The Surveillance Epidemiology and End Results database was analyzed to explore the pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy as well as the use of adjuvant radiation in this population METHODS Identified were patients from 2004 to 2006 with clinically staged Tic 2cNx-OMO prostate adenocarcinoma who underwent radical prostatectomy All patients had complete clinical and pathologic data The use of postoperative radiation was recorded Logistic regression analysis was performed to identify unadjusted and adjusted predictors for extraprostatic disease or positive surgical margins and for adjuvant radiation use RESULTS A total of 35 642 patients were identified For those patients with Gleason 7 (4+3) and a prostate-specific antigen (PSA) level of >= 101 ng/mL or Gleason 8 to 10 with any PSA level the rate of organ confined disease with negative surgical margins was found to be <50% Of those with indications for adjuvant radiation 111% received the treatment CONCLUSIONS This large population-based study detailed the risk of extraprostatic extension and positive surgical margins in a broad setting across multiple regions and communities as well as the use of adjuvant radiation for these patients As of 2006 111%

• 出版日期2010-12-15