sp(3) C-H Bond Activation with Ruthenium(II) Catalysts and C(3)-Alkylation of Cyclic Amines

作者：Sundararaju Basker; Achard Mathieu; Sharma Gangavaram V M; Bruneau Christian^*

来源：Journal of the American Chemical Society, 2011, 133(27): 10340-10343.

DOI：10.1021/ja203875d

A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.

• 出版日期2011-7-13