Antimalarial Drug Susceptibility of Plasmodium vivax in the Republic of Korea

作者：Chotivanich Kesinee; Sattabongkot Jetsumon; Choi Yien Kyong; Park Jae Sun; Sritabal Juntima; Lim Chae Seung; Udomsangpetch Rachanee; White Nicholas J^*; Lee Won Ja

来源：The American Journal of Tropical Medicine and Hygiene, 2009, 80(6): 902-904.

DOI：10.4269/ajtmh.2009.80.902

The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC(50)) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL. pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6 P = 0.004), piperaquine and chloroquine (r = 0.6 P = 0.008), and piperaquine and primaquine IC(50) values (r = 0.5, P = 0.01). Compared with P vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate.

• 出版日期2009-6
• 单位河北医科大学