Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei)

作者：Wilson Sanchez Griselda; Moreno Felix Carolina; Velazquez Carlos; Plascencia Jatomea Maribel; Acosta Anita; Machi Lara Lorena; Aldana Madrid Maria Lourdes; Ezquerra Brauer Josafat Marina; Robles Zepeda Ramon; Burgos Hernandez Armando^*

来源：Marine Drugs, 2010, 8(11): 2795-2809.

DOI：10.3390/md8112795

• antimutagenicity
• antiproliferation
• cultured shrimp

An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B(1), showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB(1) and proliferation of a cancer cell line.

• 出版日期2010-11