A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

作者：Ayaz Muhammad; Dietrich Justin; Hulme Christopher^*

来源：Tetrahedron Letters, 2011, 52(38): 4821-4823.

DOI：10.1016/j.tetlet.2011.06.115

• Petasis reaction
• Multicomponent reaction
• Quinoxaline
• Intramolecular cyclization
• Microwave

This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.

• 出版日期2011-9-21