Preparation of a bioactive and degradable poly(epsilon-caprolactone)/silica hybrid through a sol-gel method

作者：Rhee SH^*; Choi JY; Kim HM

来源：Biomaterials, 2002, 23(24): 4915-4921.

DOI：10.1016/S0142-9612(02)00251-X

• poly(epsilon-caprolactone)
• silica
• hybrid
• bioactivity
• biodegradability

A bioactive and degradable poly(epsilon-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly(epsilon-caprolactone) was prepared by the reaction with alpha,omega-hydroxyl poly(epsilon-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicyclo[2,2,2,]octane as a catalyst. It was then co-condensed with tetraethyl orthosilicate and calcium nitrate tetrahydrate via a sol-gel method. The bioactivity of the poly(epsilon-caprolactone)/silica hybrid was assessed using simulated body fluid and low crystalline apatite was successfully formed on its surface after soaking for I week at 36.5degreesC. Its biodegradability was evaluated in the phosphate buffered saline and the degradability was mostly come from the poly(epsilon -caprolactone) phase in the hybrid. It means that this hybrid is likely to be applicable to a bioactive and degradable bone substitute.

• 出版日期2002-12