Association of cytokine gene polymorphisms with rate of decline in lung function

作者：Yucesoy Berran^*; Kurzius Spencer Margaret; Johnson Victor J; Fluharty Kara; Kashon Michael L; Guerra Stefano; Luster Michael I; Burgess Jefferey L

来源：Journal of Occupational and Environmental Medicine, 2008, 50(6): 642-648.

DOI：10.1097/JOM.0b013e31816515e1

Objective: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in I second (FEV1). Methods: Functional polymorphisms in the TNF alpha, TGF beta 1, IL-1 beta, IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. Results: A protective effect was found between the presence of the TGF beta 1 - 509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNF alpha -308 (P = 0.010) and GG genotype at TNF alpha-238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNF alpha -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. Conclusions: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.

• 出版日期2008-6