Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series

作者：Pecanha Paulo Mendes; de Souza Stella; Falqueto Alo Sio; Grao Veloso Tania Regina; Ventura Lirio Ludmila; Goncalves Ferreira Carlos Urbano Jr; Santos Aline Rocha; Costa Helbia Garcia; Meirelles de Souza Lucia Renata; Tuon Felipe Francisco^*

来源：International Journal of Antimicrobial Agents, 2016, 48(4): 428-430.

DOI：10.1016/j.ijantimicag.2016.06.011

• Paracoccidioides brasiliensis
• Paracoccidioidomycosis
• Amphotericin B
• Amphotericin B lipid complex
• Liposomal amphotericin B

Amphotericin B deoxycholate is the main option for intravenous (i.v.) treatment of severe paracoccidioidomycosis (PCM). This is the first report of amphotericin B lipid complex (ABLC) in the treatment of PCM. Among 28 patients, cure was achieved in all patients (100%) using ABLC. Mean and median daily doses of ABLC were 3.39 mg/kg/day and 3.35 mg/kg/day, respectively. ABLC may be a choice in the treatment of severe forms of PCM or when i.v. options are required.

• 出版日期2016-10