A Co-II complex for F-19 MRI-based detection of reactive oxygen species

作者：Yu Meng; Xie Da; Phan Khanh P; Enriquez Jose S; Luci Jeffrey J; Que Emily L^*

来源：Chemical Communications, 2016, 52(96): 13885-13888.

DOI：10.1039/c6cc08207f

A fluorinated, air-stable cobalt(II) complex serves as a turn-on F-19 magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin Co-II to diamagnetic low spin Co-III resulting in a chemical shift change and enhancement in (19)FNMRsignal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by F-19 MRI, characterized by a similar to 2-3 fold enhancement in signal.

• 出版日期2016