A better method for assessment of hepatic function in hepatocellular carcinoma patients treated with radiofrequency ablation: Usefulness of albumin-bilirubin grade

作者：Hiraoka Atsushi^*; Kumada Takashi; Hirooka Masashi; Tsuji Kunihiko; Itobayashi Ei; Kariyama Kazuya; Ishikawa Toru; Tajiri Kazuto; Ochi Hirofumi; Tada Toshifumi; Toyoda Hidenori; Nouso Kazuhiro; Joko Koji; Kawasaki Hideki; Hiasa Yoichi; Michitaka Kojiro

来源：Hepatology Research, 2018, 48(3): E61-E67.

DOI：10.1111/hepr.12927

• ALBI grade
• Child-Pugh
• hepatocellular carcinoma
• ICG
• liver damage
• radiofrequency ablation

Aim: To evaluate the efficacy of the newly proposed albumin-bilirubin (ALBI) grade for therapy selection, clinical features of patients treated with radiofrequency ablation (RFA) were elucidated.
Methods: From 2000 to 2015, 1101 patients with HCC (<3cm, <= 3 tumors) treated with RFA were enrolled, with the following clinical features: 734 men and 367 women; 779 with hepatitis C virus, 153 with hepatitis B virus, 5 with hepatitis C and B, and 164 others; and Child-Pugh classification (CP) A:Bratio of 842:259. Liver damage classification (LD) using the indocyanine green retention rate at 15min and ALBI-grade were compared in regard to the prognoses of those patients.
Results: Median tumor size was 1.7cm (interquartile range, 1.4-2.2cm) and single tumors were found in 802 cases (72.8%) (tumor-node-metastasis stage of the Liver Cancer Study Group of Japan I:II:III=536:454:111). In the LD-A group, the number of cases with ALBI-grade 1, 2, and 3 were 294, 224, and 1, respectively, while those in the LD-B group were 47, 490, and 12, respectively. In the LD-C group, 19 and 14 patients were ALBI-2 and -3, respectively. Akaike Information Criterion values for CP, LD-grade, and ALBI-grade were 6015.4, 5988.8, and 5990.7, respectively. However, there was no significant difference regarding prognosis between LD-A/B (n=228) and C (n=31) (median survival time, 4.8 vs. 3.9years, P=0.0818) in CP-B, whereas a significant difference was observed regarding prognosis for ALBI-1/2 (n=232) and ALBI-3 (n=27) (median survival time, 4.8 vs. 2.7years, P=0.0168).
Conclusion:Albumin-bilirubin grade showed an assessment ability similar to that of LD-grade. Furthermore, there was a small improvement in prognosis following RFA in patients with an ALBI-grade of 3. Although only two serological parameters, albumin and total bilirubin, are used, assessment with ALBI-grade may be more useful than with LD-grade for avoiding a non-beneficial RFA procedure.

• 出版日期2018-2