Novel synthesis of aza-phthalimidine hydroxylactams

作者：Fan, Bolin; Liu, Zenglu; Tang, Mei; Xu, Yun; Tang, Xiaowei; Mao, Zhenmin^*

来源：Synthetic Communications, 2008, 38(19): 3231-3242.

DOI：10.1080/00397910802110180

• N-bromosuccinimide
• hydroxylactam
• hydroxylation

A novel and convenient synthetic route for preparing aza-phthalimidine ydroxylactams (5a-j) by N-bromosuccinimide (NBS) was developed. This method involved the substitution reactions of substrates (3a-j) with NBS via unstable intermediate bromides (4a-j) rapidly hydrolyzed into hydroxyl products in the course of the workup process.

• 出版日期2008
• 单位上海交通大学