Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based Eu-III complex

作者：Monteiro J H S K; Machado D; de Hollanda L M; Lancellotti M; Sigoli F A; de Bettencourt Dias A

来源：Chemical communications, 2017, 53(86): 11818-11821.

DOI：10.1039/c7cc06753d

Four new species [Ln(dipicNH(2))(3)](3-) (Ln = La-III, Eu-III, Gd-III, Tb-III), with the ligand dipicNH(2)(2-) (dipic = dipicolinato), were synthesized. Incubation of the Eu-III complex with glioma NG97 and pancreatic cancer PANC1 cells showed that it penetrates the cell membrane and can be used to image the cells, while also being moderately cytotoxic.

• 出版日期2017-11-7