Retinal nerve fibre layer cross-sectional area, neuroretinal rim area and body mass index

作者：Jonas Jost B; Nangia Vinay^*; Gupta Rajesh; Agarwal Shubhra; Matin Arshia; Khare Anshu; Bhate Karishma; Sinha Ajit; Bhojwani Krishna; Kulkarni Maithili; Panda Jonas Songhomitra

来源：Acta Ophthalmologica, 2014, 92(3): E194-E199.

DOI：10.1111/aos.12297

• retinal nerve fibre layer
• glaucoma
• cerebrospinal fluid pressure
• body mass index
• neuroretinal rim

Purpose
To examine associations between body mass index, neuroretinal rim area and retinal nerve fibre layer cross-sectional area (RNFLCRA) in a population-based setting.
Methods
The Central India Eye and Medical Study is a population-based study performed in a rural region of Central India. The study included 4711 subjects (aged 30+years). A detailed ophthalmic and medical examination was performed. Inclusion criteria for this study were an intra-ocular pressure <= 21mmHg, open anterior chamber angles and an axial length <= 26.5mm. Neuroretinal rim area and RNFLCRA were measured by confocal laser scanning tomography.
Results
The study included 3959 subjects fulfilling the inclusion criteria. Larger neuroretinal rim area (mean: 1.63 +/- 0.32mm(2)) was significantly (p=0.004) associated with a higher body mass index after adjusting for larger disc area (p<0.001), younger age (p<0.001), lower intraocular pressure (p<0.001), and hyperopic refractive error (p<0.001). Larger retinal nerve fibre layer cross-sectional area (mean:1.29 +/- 0.39mm(2)) was significantly associated with higher body mass index (p=0.001) after adjusting for younger age (p<0.001), shorter axial length (p<0.001), larger optic disc area (p<0.001), taller body height (p<0.001) and male gender (p=0.04).
Conclusions
In a rural Central Indian population, neuroretinal rim area and RNFLCRA as surrogates of the optic nerve fibres were related to a higher body mass index. Because body mass index is associated with cerebrospinal fluid pressure, the higher cerebrospinal fluid pressure may be associated with a larger neuroretinal rim area. It may vaguely point towards an association between cerebrospinal fluid pressure and glaucomatous optic neuropathy.

• 出版日期2014-5