The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2

作者：Li, Ziming; Xu, Ling; Tang, Naiwang; Xu, Yunhua; Ye, Xiangyun; Shen, Shengping; Niu, Xiaomin; Lu, Shun^*; Chen, Zhiwei

来源：FEBS LETTERS, 2014, 588(17): 3000-3007.

DOI：10.1016/j.febslet.2014.05.057

• Enhancer of zester homolog 2
• NF-E2-related factor 2
• Histone H3 lysine 27
• Non-small cell lung cancer

EZH2 is a key component of the polycomb PRC2 complex and functions as a histone H3 Lys27 (H3K27) trimethyltransferase. Here we show that EZH2 is down-regulated in human non-small cell lung cancer and low EZH2 expression predicts poor survival. Further we demonstrate that EZH2 inhibits lung cancer cell proliferation and colony formation in vitro and growth in vivo. We found that EZH2 binds to the promoter of Nrf2, where it increases H3K27me3 and represses Nrf2 expression. Finally, Nrf2 seems to be essential for the hyper proliferation of lung cancer cells in the absence of EZH2.

• 出版日期2014-8-25
• 单位上海中医药大学; 上海交通大学