SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells

作者：Zhang Yu; Huang Shuyan; Dong Wei; Li Lin; Feng Yunpeng; Pan Lina; Han Zhenkun; Wang Xiuli; Ren Guoling; Su Dongmei; Huang Baiqu; Lu Jun^*

来源：Cancer Letters, 2009, 277(1): 29-37.

DOI：10.1016/j.canlet.2008.11.014

• SOX7
• Colorectal cancer
• DNA methylation
• Apoptosis
• Wnt pathway

The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed beta-catenin-mediated transcriptional activity.

• 出版日期2009-5-8
• 单位东北师范大学; 哈尔滨医科大学