No significant association between RELN polymorphism and autism in case-control and family-based association study in Chinese Han population

作者：He, Yiqun; Xun, Guanglei; Xia, Kun; Hu, Zhengmao; Lv, Luxian; Deng, Zemin; Zhao, Jingping^*

来源：Psychiatry Research, 2011, 187(3): 462-464.

DOI：10.1016/j.psychres.2010.04.051

• Autism
• Reelin gene
• Polymorphism

The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. Both case-control analysis and transmission disequilibrium test (TDT) found no evidence of significant association. The results do not support previous positive findings and suggest that the four single-nucleotide polymorphisms (SNP) of RELN are unlikely to be associated with childhood autism in Chinese Han population.

• 出版日期2011-5-30
• 单位新乡医学院; 中南大学