Asymmetric Synthesis of Both Enantiomers of Protected 5-Hydroxynorvaline by Hetero-Diels-Alder Addition of ethyl 2-Nitrosoacrylate to (R)- and (S)-1-Phenylbutyl Vinyl Ether

作者：Massen Zoe S; Gallos John K^*

来源：Journal of Heterocyclic Chemistry, 2012, 49(5): 1214-1217.

DOI：10.1002/jhet.907

Both enantiomers of protected 5-hydroxynorvaline were prepared by hetero-Diels-Alder addition of ethyl 2-nitrosoacrylate to readily available (R)- and (S)-1-phenylbutyl vinyl ether and a further three-step manipulation. Attempted synthesis of (+/-)-vigabatrin from protected (+/-)-5-hydroxynorvaline was unsuccessful.

• 出版日期2012-9