Hemoglobin A(1c) proportion, mortality rate, and risk factors for death in diabetic patients with severe hypoglycemia: A multicenter retrospective survey over ten years

作者：Li, Wan-gen^*; He, Xin-lian; Zhang, Tong; Xiang, Guang-da; Ran, Jian-min; Peng, Cheng; Zhang, Hong

来源：Diabetes Research and Clinical Practice, 2011, 93(1): 17-20.

DOI：10.1016/j.diabres.2011.02.025

• Diabetes
• Severe hypoglycemia
• HbA(1c)
• Mortality rate
• Risk factor

Objective: To investigate the HbA(1c) proportion and mortality rate across diabetic patients with severe hypoglycemia and the risk factors for death.
Methods: All the diabetic patients with severe hypoglycemia were divided into HbA(1c) < 6.5% group and HbA(1c) >= 6.5% group. The proportion of HbA(1c), mortality rate and the risk factors for death were analyzed. Common causes for severe hypoglycemia were also analyzed.
Results: The percentages of HbA(1c) in the HbA(1c) < 6.5% and HbA(1c) >= 6.5% groups were 51.2% and 48.8%, respectively. The mortality rates were not significantly different between the 2 groups (5.3% vs. 5.1%, chi(2) = 0.01, p = 0.17). Binary logistic regression analysis revealed that in both groups, creatinine, aspartate aminotransferase, and uric acid levels were the risk factors for death. In the HbA(1c) < 6.5% and HbA(1c) >= 6.5% groups, 65.0% and 64.2% showed common causes of severe hypoglycemia, respectively.
Conclusions: With respect to severe hypoglycemia, equal attention should be paid to patients with an HbA(1c) level of >= 6.5% and those with an HbA(1c) level of < 6.5%. The mortality rate is approximately 5% in severe hypoglycemia no matter how the HbA(1c) level is. Creatinine, aspartate aminotransferase, and uric acid are the main risk factors in both groups. Two-thirds of severe hypoglycemia cases could be prevented.

• 出版日期2011-7
• 单位中南大学; 中国人民解放军广州军区武汉总医院; 广州医科大学