Amphiphilic cholesteryl grafted sodium alginate derivative: Synthesis and self-assembly in aqueous solution

作者：Yang, Liqun^*; Zhang, Bifang; Wen, Liqun; Liang, Qiuyi; Zhang, Li Ming

来源：Carbohydrate Polymers, 2007, 68(2): 218-225.

DOI：10.1016/j.carbpol.2006.12.020

• sodium alginate
• cholesterol
• amphiphilic
• self-assembly
• critical aggregation concentration

A novel water soluble amphiphilic sodium alginate derivative grafted with 3 cholesteryl groups per 100 hexuronic acid residues (CSAD-3) has been first synthesized with N,N'-dicyclohexylcarbodiimide as a coupling agent and 4-(N,N'-dimethylamino)pyridine as a catalyst at room temperature. The result of fluorescence analysis shows that CSAD-3 forms self-aggregates in 0.15 mol/L aqueous NaCl solution and its critical aggregation concentration (CAC) is 0.33 g/L. The value of CAC decreases with increase of the concentration of aqueous NaCl solution. The CSAD-3 self-aggregates are able to encapsulate hydrophobic compounds like pyrene. The hydrodynamic diameter of CSAD-3 self-aggregates in aqueous NaG solution is 136 nm determined by dynamic light scattering measurement. The oblate particles with the size about 100-200 nm are observed in the negatively dyed TEM image of CSAD-3 self-aggregates.

• 出版日期2007-3-21
• 单位中山大学