Dynamical simulation of magnetic nano-drug targeting

作者：Kang, Bin; Song, Wei; Zhang, Yan; Dai, Yaodong; Chen, Da

来源：Chinese Journal of Computational Physics, 2007, 24(5): 585-590.

• Arteriole
• Finite element simulation
• Magnetic nanodrug
• Transmission dynamics

We describe an unsteady flow model of blood in arterioles of normal and tumor tissues, and show effect of external magnetic field on flow field of blood considering coupling of magnetic field and flow. Traditional single-phase model is modified by a discrete method, and dynamical simulation with a finite element route is used to investigate transmission of magnetic nano-drug in arteriole. The result indicates that the capture of nano-drug by magnetic field is entirely different from that of micro-drug by magnetic field. The trajectory of nano-drug is primarily coincident with the streamline of blood flow. However, the effect of magnetic field on the blood flow is obvious due to the presence of magnetic nano-drug. Several whirlpools are formed near the magnet. In tumor arteriole these whirlpools stay for a long time and the magnetic nano-drug is efficiently captured by external magnetic field.

• 出版日期2007-9
• 单位南京航空航天大学