An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base

作者：Guo, Mengping^*; Chen, Bo; Zhu, Qiming; Jin, Hua; Peng, Qiuling; Kang, Yanping

来源：Molecules, 2017, 22(8): 1277.

DOI：10.3390/molecules22081277

• arylated pyridines
• synthesis
• transition-metal-free
• base
• catalysis

An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 degrees C with K2CO3 as catalyst.

• 出版日期2017-8
• 单位宜春学院