Acceleration of arylzinc formation and its enantioselective addition to aldehydes by microwave irradiation and aziridine-2-methanol catalysts

作者：Braga Antonio L^*; Paixao Marcio W; Westermann Bernhard; Schneider Paulo H; Wessjohann Ludger A

来源：Journal of Organic Chemistry, 2008, 73(7): 2879-2882.

DOI：10.1021/jo702413n

The formation and 2-amino alcohol catalyzed addition of arylzinc reagents from and with boronic acids, respectively, is drastically accelerated to a few minutes under microwave irradiation without loss of enantioselectivity (up to 98% ee). Of the amino acid derived catalysts tested, the conformationally restricted bulky substituted aziridine-2-methanols derived from serine show the best overall performance in the formation of diarylmethanols.

• 出版日期2008-4-4