First-Trimester Maternal Serum C-reactive Protein as a Predictor of Third-Trimester Impaired Glucose Tolerance

作者：Berggren Erica K^*; Roeder Hilary A; Boggess Kim A; Moss Kevin; Offenbacher Steven; Campbell Emilia; Grotegut Chad A

来源：Reproductive Sciences, 2015, 22(1): 90-93.

DOI：10.1177/1933719114532843

• high-sensitivity C-reactive protein
• early pregnancy predictors
• impaired glucose tolerance
• maternal serum markers

Objective: We evaluated whether first-trimester high-sensitivity C-reactive protein (hsCRP), a suggested marker of pregnancy-associated hyperglycemia, predicts third-trimester impaired glucose tolerance (IGT) in a secondary analysis of a prospective cohort of nondiabetic singletons enrolled at <26 weeks gestation.
Study Design: We measured the association between hsCRP collected at <14 weeks among women classified as IGT (gestational diabetes screening results, 135 to <200 mg/dL) and those among normoglycemic women. Multivariable modeling estimated the association between log hsCRP and IGT, adjusted for maternal body mass index (BMI).
Results: Among 300 women, 13% (39 of 300) had IGT. The hsCRP was positively associated with glucose (P = .005). Compared with normoglycemic women, women with IGT had higher log hsCRP (0.87 0.66 vs 0.67 +/- 0.60, P = .04), but the association was not significant in adjusted models (adjusted odds ratio 1.20, 95% confidence interval 0.65-2.21). The hsCRP did not predict third-trimester IGT in this analysis when BMI is considered.
Conclusion: Early identification of women at risk of IGT remains a priority, but the contribution of maternal BMI appears greater than hsCRP.

• 出版日期2015-1