A pooled analysis of alcohol intake and colorectal cancer

作者：Wang, Yue; Duan, Hong; Yang, Helen; Lin, Jie^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(5): 6878-6889.

• Alcohol intake
• colorectal neoplasms
• meta-analysis

Object: In order to provide an updated quantification of the association between alcohol intake and colorectal cancer, we conducted a meta-analysis of published observational studies. Method: Two cohort and 22 case-control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before July 2014. Data were extracted independently by two reviewers. Random effects meta-analyses, subgroup analyses, and meta regression were performed for modeling the dose-response relation. Result: The pooled relative risk (RR) for any alcohol intake compared with non/occasional drinking was 1.13 [95% confidence interval (CI), 1.09-1.17]. The RRs were 1.07 (95% CI, 1.02-1.13), 1.23 (95% CI, 1.15-1.32) and 1.37 (95% CI, 1.26-1.49) for light (<= 12.5 g/day), moderate (12.6 to 49.9 g/day) and heavy drinking (>= 50 g/day), respectively. The risks were consistent in the subgroup analyses of sex and tumor site. Conclusion: This meta-analysis provides strong evidence for an association between alcohol intake and colorectal cancer risk.

• 出版日期2015
• 单位郑州大学; 辽宁省肿瘤医院