Decrease of the atrial fibrillatory rate, increased organization of the atrial rhythm and termination of atrial fibrillation by AZD7009

作者：Aunes Jansson Maria^*; Edvardsson Nils; Stridh Martin; Sornmo Leif; Frison Lars; Berggren Anders

来源：Journal of Electrocardiology, 2013, 46(1): 29-35.

DOI：10.1016/j.jelectrocard.2012.09.002

• Atrial fibrillatory rate
• Pharmacological conversion
• Atrial fibrillation

Background: The atrial fibrillatory rate (APR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development. %26lt;br%26gt;Methods: Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST cancellation the APR, its standard deviation (SD), the exponential decay and the atrial electrogram amplitude were determined as 3-min averages. %26lt;br%26gt;Results: The mean APR rapidly decreased by 43% from baseline (394 +/- 38 to 225 +/- 61 fibrillations/min, p = 0.0003) on AZD7009, but not on placebo. The SD of the AFR and the exponential decay decreased in parallel. In 2 of 8 patients, termination of AF occurred after the APR had decreased by 58% and 53%, respectively. %26lt;br%26gt;Conclusions: The APR may potentially serve as a biomarker of electrophysiological effects in early evaluation of rhythm control agents.

• 出版日期2013-2