A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

作者:Kim Ikyon*; Won Hye Kyoung; Choi Jihyun; Lee Ge Hyeong
来源:Tetrahedron, 2007, 63(52): 12954-12960.
DOI:10.1016/j.tet.2007.10.037

摘要

A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields.

  • 出版日期2007-12-24