A Bisindole Alkaloid with Hedgehog Signal Inhibitory Activity from the Myxomycete Perichaena chrysosperma

作者:Shintani Akinori; Toume Kazufumi; Rifai Yusnita; Arai Midori A; Ishibashi Masami*
来源:Journal of Natural Products, 2010, 73(10): 1711-1713.
DOI:10.1021/np1002687

摘要

6-Hydroxy-9'-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9'-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.

  • 出版日期2010-10