Upregulation of MHC class I expression following dengue virus infection: the mechanism at the promoter level

作者：Yossef Rami; Rosental Benyamin; Appel Michael Y; Hershkovitz Oren; Porgador Angel^*

来源：Expert Review of Anti-Infective Therapy, 2012, 10(3): 285-287.

DOI：10.1586/ERI.12.7

• class I regulatory complex
• dengue virus
• HLA-A2 gene
• NF-kappa B

Unlike many other viruses that downregulate MHC class I expression on infected cell membranes, flaviviruses were reported to upregulate the MHC class I expression. Dengue virus was shown to induce HLA class I expression; however, the precise transcriptional mechanism that is used by the virus remains unclear. This article assessed the findings of a recently published report describing the mechanism used by dengue virus to induce HLA-A2 expression and characterizing the transcription factors that are involved. The study showed that p50/p65 and p65/65 NF-kappa B dimers bind to the class I regulatory complex within the HLA-A2 promoter. This finding and its significance for the design of possible antiviral therapeutic agents are discussed in this article.

• 出版日期2012-3