Association between glutathione S-transferase T1 null genotype and glioma susceptibility: a meta-analysis

作者：Zhang Benping; Wang Jianjiao; Niu Hongshuang; Li Yang; Yuan Fei; Tian Yu; Zhou Fenggang; Hao Zhen; Zheng Yongri; Li Qingsong^*; Wang Weizhi

来源：Tumor Biology, 2014, 35(3): 2081-2086.

DOI：10.1007/s13277-013-1276-z

• Glioma
• Susceptibility
• Glutathione S-transferase T1
• Polymorphism
• Meta-analysis

The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However, these studies report inconsistent results. In order to get this precise result, a meta-analysis was conducted by calculating the pooled odds ratios (OR) and the 95 % confidence intervals (95 % CI). Eleven case-control research studies with a total of 2,416 glioma cases and 4,850 controls were included into this meta-analysis. The combined results based on all studies showed that there was no significant association between the GSTT1 null allele and glioma risk (OR = 1.188, 95 % CI = 0.929-1.520, P (heterogeneity) = 0.003, P = 0.170). In the subgroup analysis, the same results were found in our work. There was no risk of publication bias in this meta-analysis. Our results suggest that GSTT1 null genotype was not associated with the increased risk of glioma.

• 出版日期2014-3
• 单位哈尔滨医科大学