科研之友
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摘要
The aim of the present study was to determine the cost effectiveness of a noninvasive prenatal diagnosis (PND) program for -thalassemia (-thal) using ultrasound scan. During a 5-year period, 1923 pregnancies at-risk for homozygous (0)-thal were recruited into the noninvasive PND program. There were 1452 women who avoided invasive testing because of a normal ultrasound scan. The remaining 471 showed abnormal fetal ultrasonographic findings, and invasive testing was recommended. The overall cost of running the noninvasive PND program was US$213,383, while the cost of running the invasive program would have been US$554,810. The total savings were estimated at US$356,499 for women with an unaffected pregnancy with a net saving of US$246 per capita. This study demonstrated that it is cost effective to run a noninvasive PND program for -thal in an area where the disease is prevalent, and therefore effectively avoiding an invasive test in unaffected pregnancies.
- 出版日期2016-8
- 单位广州医科大学; 广州市妇女儿童医疗中心
