Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease

作者：Chopra Atul R; Louet Jean Francois; Saha Pradip; An Jie; DeMayo Franco; Xu Jianming; York Brian; Karpen Saul; Finegold Milton; Moore David; Chan Lawrence; Newgard Christopher B; O'Malley Bert W^*

来源：Science, 2008, 322(5906): 1395-1399.

DOI：10.1126/science.1164847

Hepatic glucose production is critical for basal brain function and survival when dietary glucose is unavailable. Glucose- 6- phosphatase (G6Pase) is an essential, rate- limiting enzyme that serves as a terminal gatekeeper for hepatic glucose release into the plasma. Mutations in G6Pase result in Von Gierke's disease ( glycogen storage disease-1a), a potentially fatal genetic disorder. We have identified the transcriptional coactivator SRC-2 as a regulator of fasting hepatic glucose release, a function that SRC- 2 performs by controlling the expression of hepatic G6Pase. SRC- 2 modulates G6Pase expression directly by acting as a coactivator with the orphan nuclear receptor ROR alpha. In addition, SRC- 2 ablation, in both a whole- body and liver- specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC- 2 as a critical regulator of mammalian glucose production.

• 出版日期2008-11-28