Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis

作者：Wendel Angela A; Lewin Tal M; Coleman Rosalind A^*

来源：Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 2009, 1791(6): 501-506.

DOI：10.1016/j.bbalip.2008.10.010

• Glycerolipid
• Phospholipid
• Membrane
• Lipid droplet
• Lysophosphatidic acid
• Diacylglycerol

Four homologous isoforms of glycero 1-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA. This step initiates the synthesis of all the glycerolipids and evidence from gain-of-function and loss-of-function studies in mice and in cell culture strongly suggests that each isoform contributes to the synthesis of triacylglycerol. Much work remains to fully delineate the regulation of each GPAT isoform and its individual role in triacylglycerol synthesis.

• 出版日期2009-6