Assessing determinants of self-medication with antibiotics among Portuguese people in the Algarve Region

作者：Ramalhinho Isabel^*; Cordeiro Clara; Cavaco Afonso; Cabrita Jose

来源：International Journal of Clinical Pharmacy, 2014, 36(5): 1039-1047.

DOI：10.1007/s11096-014-9992-z

• Antibiotics
• Antimicrobial resistance
• Determinants of self-medication
• Drug use
• Non-prescription use
• Portugal

Background Misuse of antibiotics gives rise to numerous individual and societal problems, among which antimicrobial resistance is currently a major worldwide concern. Understanding cultural features in the public%26apos;s attitudes and behaviours regarding antibiotics and their use is a prerequisite to developing effective educational interventions. Objective To estimate the prevalence of selfmedication with antibiotics and evaluate the predictive factors associated with such self-medication. Setting The general population, drawn from town halls, supermarkets, hotels, food malls, restaurants, sports groups and Senior Colleges. Methods A cross-sectional study was conducted by convenience sampling the adult population living in the Algarve, Portugal. The information about self-medication with antibiotics was assessed by using a validated selfadministrated questionnaire. Factors associated with selfmedication were identified through bivariate analysis and a logistic regression model. Results Of the 2,000 questionnaires distributed, 1,198 were returned, representing a response rate of 59.9 %. A total of 1,192 individuals were included in the study. The mean age was 46.6 +/- 16.9 years and 48.7 % (95 % CI 46-52 %) were male. The majority of individuals said that they had returned the leftover antibiotics to the pharmacy for destruction. However, 268 respondents (22.5 %, 95 % CI 20-25 %) said they had disposed of their medication through the garbage or the sewage system. 218 respondents (18.9 %, 95 % CI 17-21 %) were assumed to have already taken antibiotics without a prescription and 267 (23 %, 95 % CI 21-25 %) reported having leftover antibiotics at home. The factors that influence self-medication with antibiotics were age; in particular, the risk is higher in the youngest group 18-34 years: OR 4.57 (95 % CI 2.23-9.39; p %26lt; 0.001), and in the 50-64 year group: OR 2.33 (95 % CI 1.08-5.03; p = 0.03); and the male gender: OR 2.88 (95 % CI 1.86-4.46; p %26lt; 0.001). The risk was lower in respondents who said that it was not easy to get antibiotics without a prescription: OR 0.07 (95 % CI 0.05-0.12; p %26lt; 0.001). Conclusion Non-prescription acquisition, age and gender could be determinants of self-medication with antibiotics among Portuguese people in the Algarve region.

• 出版日期2014-10
• 单位河北医科大学