Acute and Subacute Oral Toxicity Evaluation of Eriobotrya japonica Leaf Triterpene Acids in ICR Mice

作者：Li, Feng^*; Li, Yijia; Li, Qingxian; Shi, Xianai; Guo, Yanghao^*

来源：Evidence-Based Complementary and Alternative Medicine, 2017, 2017: 4837839.

DOI：10.1155/2017/4837839

• OLEANOLIC ACID
• URSOLIC ACID
• COROSOLIC ACID
• BIOACTIVE TRITERPENES
• MASLINIC ACID
• APOPTOSIS
• CANCER
• INDUCTION
• OBESITY
• LEAVES

The interest focusing on Eriobotrya japonica leaf triterpene acid (ELTA) has increased recently because of its beneficial effects on health. However, there has been a lack of experimental data on its toxicity. The present study therefore was conducted to evaluate its toxicity in ICR mice. The results showed that ELTA produced neither mortality nor toxicity of the main organs in ICR male and female mice in both acute (0.30, 0.65, 1.39, and 3.00 g center dot kg(-1) body weight) and subacute (150, 300, and 600mg center dot kg(-1) BW) 28-day toxicity studies. Because of lacking apparently adverse effects found in the hematology, clinical biochemistry, and histopathology evaluation, results of the present study together with the beneficial effects make ELTA as a promising dietary supplement and indicated that ELTA administered orally might have a large safety margin for human.

• 出版日期2017
• 单位福州大学