Analysis of esmolol and landiolol on elderly patients in the perioperative period with gastric surgery

作者：Yang, Xianhui; Li, Shumin^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(12): 12755-12760.

• Esmolol
• landiolol
• surgery for the elderly patients
• anesthesia
• cognitive function

Objective: This paper aims to analyze the controlling effect on rhythm of the heart by esmolol and landiolol during gastric surgery on elderly patients and to analyze whether they affect anesthesia doses used for surgery, which probably affects postoperative cognitive function. Methods: 45 patients who conducted radical surgery for gastric cancer were collected as study objects and they were randomly divided as group P, group E and group L, and the three groups were respectively given moderate placebo, esmolol and landiolol during the surgery. And then during the surgery, HR (Heart Rate) and MAP (Mean Arterial Pressure) of patients were observed, together with time of opening eyes and extubation time. Bis (Bispectral Index) value was maintained within 40-50. The dose of inhalation Sevoflurane at every moment in the surgery was recorded as well. And finally, their preoperative cognitive level and postoperative cognitive level were evaluated by MMSE (mini-mental state examination). Results: the average eye-open time in group E and group L were 14.3+/-3.24 min and 15.5+/-2.26 min, respectively, 4.5 min and 3.3 min ahead of group P, and the average extubation time in group E and group L were 18.8+/-2.70 min and 19.1+/-2.33 min, respectively, 7 min and 6.7 min ahead of group P. The average range of HR and MAP of patients in group P, group E and group L were 77.29-91.4 times/min, 70.8-77.8 times/min and 73.4-79.2 times/min, and 79-95.8 mmHg, 70.8-87.8 mmHg and 73.4-88 mmHg, respectively. And early postoperative cognitive function recovery of patients in group E and group L was 2 d and 4 d advanced compared to group P. The dose range of sevoflurane given during the surgery in group P, group E and group L were 2-1.1 MAC, 0.7-0 MAC and 1.4-0.4 MAC. Conclusion: Esmolol and landiolol have certain controlling function over HR and blood pressure during the surgery for the elderly patients, and landiolol is more stable in reducing HR and blood pressure. And at the same degree of anesthesia, esmolol and landiolol can reduce sevoflurane inhalation dose which helps to advance patients' eye-open time and extubation time, consequently to improve their early cognitive function recovery.

• 出版日期2016
• 单位郑州大学