Major Life Events as Potential Triggers of Sudden Cardiac Arrest

作者：Wicks April F^*; Lumley Thomas; Lemaitre Rozenn N; Sotoodehnia Nona; Rea Thomas D; McKnight Barbara; Strogatz David S; Bovbjerg Viktor E; Siscovick David S

来源：Epidemiology, 2012, 23(3): 482-485.

DOI：10.1097/EDE.0b013e31824d5d82

Background: We investigated the risk of sudden cardiac arrest in association with the recent loss of, or separation from, a family member or friend. %26lt;br%26gt;Methods: Our case-crossover study included 490 apparently healthy married residents of King County, Washington, who suffered sudden cardiac arrest between 1988 and 2005. We compared exposure to spouse-reported family/friend events occurring %26lt;= 1 month before sudden cardiac arrest with events occurring in the previous 5 months. We evaluated potential effect modification by habitual vigorous physical activity. %26lt;br%26gt;Results: Recent family/friend events were associated with a higher risk of sudden cardiac arrest (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.1-2.4). ORs for cases with and without habitual vigorous physical activity were 1.1 (0.6 -2.2) and 2.0 (1.2-3.1), respectively (interaction P = 0.02). %26lt;br%26gt;Conclusions: These results suggest family/friend events may trigger sudden cardiac arrest and raise the hypothesis that habitual vigorous physical activity may lower susceptibility to these potential triggers.

• 出版日期2012-5